The research chemical Letrozole has been around for a while and was first discovered to help treat women with breast cancer. More recently there has been encouraging news for women around the globe who struggle to get pregnant through the use of Letrozole for fertility treatment.
Research so far with Letrozole for infertility
A recent study showed a significant improvement in the pregnancy rate in IVF under the influence of the aromatase inhibitor letrozole. The scientists examined 126 women between the ages of 21-39 years with endometriosis cysts on the ovaries who had previously not had a successful IVF. In addition to the standard GnRH analogs Enatone (leuprorelin) for down-regulation, one group received the aromatase inhibitor letrozole dosage in tablet form (5 mg daily) for two months. Before the start:
- the numbers of follicular cysts were counted
- size of the endometriosis cysts checked
- the level of the FSH value in the blood was determined
- There were no differences between the groups here.
After treatment, the women with letrozole had a larger number of follicles and their endometriosis cysts had decreased. However, it became clearer that when fertilized:
- The letrozole group had more mature eggs
- More fertilized eggs and
- Extra embryos
However, the effect of the drug is shown even longer. Because not only the fertilization was more promising, the pregnancy rates were also significantly higher! 50% of women using letrozole became pregnant. In contrast, only 20% of women without letrozole. And the differences weren’t over yet. Of the women in the aromatase inhibitor group, 40% gave birth to a baby, while only 17% of women without letrozole had a live birth.
There are rarely studies that show such significant differences. The hope remains that further studies can confirm this result and that as many women as possible can be spared the grief of a failed IVF or abortion.
Fertility Disorders – Letrozole for PCOS sufferers
Letrozole is an aromatase inhibitor and can help women with the polycystic ovarian syndrome (PCOS) meet their desire to have children. In a direct comparative study in the New England Journal of Medicine, the number of live births was even higher than under the current standard therapy with Clomiphene. Many experts are in favor of letrozole over Clomiphene, which was teratogenic in some animal experiments.
About 5 to 10 percent of all women of childbearing age have PCOS. This is characterized by the combination of oligo or anovulation, high androgen levels, and polycystic ovaries. A common result is fertility disorders that have been treated with Clomiphene. Clomiphene blocks estrogen receptors in the hypothalamus and thus simulates an estrogen deficiency. This results in an increased release of gonadotropins and thus hyperovulation.
Letrozole vs. Clomiphene
The most common side effects of clomiphene include multiple pregnancies. In contrast to clomiphene, the aromatase inhibitor letrozole inhibits the synthesis of estrogens. This creates an estrogen deficiency, which also triggers counter-regulation in the pituitary gland. However, the number of mature eggs is lower than that of clomiphene, which could limit the number of multiple pregnancies.
Results from a Letrozole dosage
The results of the study from the US Reproductive Medicine Network were carried out at ten centers now conclude:
A total of 750 infertile women aged 18 to 40 years who had been diagnosed with PCOS and were treated with clomiphene or letrozole over a maximum of five cycles.
The goal of delivery from a healthy woman was achieved with letrozole in 103 out of 374 women (27.5 percent), while in the clomiphene it was only 72 out of 376 women (19.1 percent) who gave birth. Richard Legro of Penn State University in Hershey calculated a rate ratio of 1.44, which was statistically significant with a 95 percent confidence interval of 1.10 to 1.87.
Possible Letrozole Side Effects
The drug works by lowering estrogen levels to encourage ovulation. Due to this, it can cause women to suffer from some side effects such as Bloating, breast pain, blurred vision, dizziness, fatigue, headaches, hot flashes, trouble sleeping, upset stomach and unusual menstrual bleeding.
What is Letrozole?
The drug Letrozole is also known as Femara. It is an aromatase inhibitor and it was first used for medical purposes in 1996. It is used to treat hormone-responsive breast cancer following surgery. The drug has the ability to lower estrogen levels in postmenopausal women. It can help slow the growth of some forms of breast cancer which need estrogen to grow within the body. The FDA Food and Drug Administration in the US approved the drug for the treatment of local or metastatic breast cancer. The action of letrozole also has also shown positivity in pretreatment for pregnancy termination, gynecomastia, and endometriosis.
Letrozole For Sale
As mentioned earlier Letrozole for fertility is now big news and gives women the chance of having babies. This can be the first step before the trialing IVF treatment that can be expensive. Peptides USA supply this research chemical and more to help all of the above studies to go ahead.