In this article, we provide some tips on how to find the best research company online for where to buy Raloxifene. We cover some points to consider when buying research chemicals. Plus we look at how and what Raloxifene can do!
History of Raloxifene Hydrochloride or Evista
Raloxifene hydrochloride was developed by Eli Lilly & Company and was approved for distribution by the FDA in the United States in 1997. The initial use of this drug is for the treatment of osteoporosis due to its capability to enhance bone density. In 2007 The FDA extended the uses and now it includes reducing the risk of invasive breast cancer in two groups. First postmenopausal women with osteoporosis and second postmenopausal women at high risk for invasive breast cancer. Today, raloxifene is a very popular treatment in clinical medicine and is approved for sale in over 50 countries.
Description of Raloxifene
Raloxifene is a second-generation selective estrogen receptor modulator (SERM) of the benzothiophene family. The substance has a similar effect to tamoxifen. It exhibits antagonist properties by blocking the estrogen receptor, while in some tissues it acts as an estrogen receptor agonist (activator). While raloxifene is a potent antiestrogen in breast and uterine tissue, it appears to be estrogenic in the bone. This allows bone density to be protected by mimicking the beneficial effects of endogenous estradiol. In this respect, it is different from tamoxifen, which acts as an antiestrogen in both the chest and bones.
Raloxifene is FDA approved for the prevention and treatment of osteoporosis in postmenopausal women. The substance is also being studied for several other potential uses, such as cardiovascular disease prevention, breast cancer, gynecomastia, prostate cancer, acromegaly, and uterine cancer.
A Brief Guide to Raloxifene
As an antiestrogen, athletes and bodybuilders can use raloxifene hydrochloride to fight estrogenic side effects caused by non-flavoring or estrogenic anabolic steroids. In particular, it is used for the treatment of gynecomastia. A pediatric study on persistent pubertal gynecomastia in 2004 compared the effect of treatment with raloxifene hydrochloride and tamoxifen. The study involved 38 patients with an average age of 15 years, suffering from gynecomastia for about 2 years. The treatment was carried out for 3-9 months. The improvement in the condition was reported in 91% of those taking raloxifene and 86% of those taking Nolvadex (tamoxifen). Nonetheless, the achievement rate of treatment with raloxifene was considered to be double that of tamoxifen (86% vs. 41%). Given its relative strength, raloxifene hydrochloride could be used instead of surgery in some cases of gynecomastia.
Characteristic of an Antiestrogen
Raloxifene could also offer some benefit as a testosterone boosting drug. This has been demonstrated in studies in a group of older men (aged 60-70 years) in which daily doses of 120 mg were able to increase serum testosterone levels and bioavailability by 20%. Although these indications are not high, they demonstrate an antiestrogenic effect when it comes to testosterone production. Raloxifene hydrochloride can be used as an adjunct to HCG injections during a post-cycle testosterone recovery program. The same study showed that raloxifene hydrochloride may have a partial estrogenic effect on serum lipids with a tendency to lower all cholesterol levels (total cholesterol, LDL, and HDL).
Raloxifene Side Effects
There are some negative sides to inhibiting the actions of estrogen that need to be considered in the study. On the one hand, estrogen favors IGF-1 levels. Studies in patients with acromegaly (a disease caused by overproduction of the hormone somatotropin by the pituitary gland) show that taking 60 mg of raloxifene hydrochloride twice a day is able to consistently suppress IGF-1 levels by an average of 16%. Estrogen also has positive anabolic effects in terms of increasing androgen receptor concentrations in certain tissues. It increases the enzymes involved in glucose uptake for tissue growth and repair. When used to stop side effects, raloxifene hydrochloride can inadvertently decrease the overall anabolic potential of the steroid cycle.
Final Word: Tips on Where to Buy Raloxifene?
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