Description of Sermorelin Acetate
Sermorelin is a synthetic analog of endogenous and triggers hormone that stimulates growth hormone release (GHRH or GRF). In particular, it contains the first 29 amino acids of the 44 in the structure of growth hormone. The biological role of Sermorelin is to stimulate the synthesis of human growth hormone produced by the pituitary gland. Sermorelin is a growth hormone-releasing factor (GHRF) or GH secretion based on its structure and activity.
Sermorelin acetate is used in clinical medicine with two main functions
The first is to diagnose pituitary deficiency. The procedure involves measuring the serum response to growth hormone for 1-2 hours after a single intravenous infusion of Sermorelin Acetate. An increase in GH levels should be reported in the hypothalamic-pituitary-growth hormone axis.
The second medical use of Sermorelin Acetate is for the treatment of growth hormone deficiency in children. Like hormonal recombinant growth drugs (rHGH, somatropin), Sermorelin acetate may provide the benefits of a steady increase in GH, including increased production of IGF-1 (insulin-like growth factor).
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Sermorelin is very specific and does not affect the levels of prolactin, LH, FSH, insulin, cortical, glucose, glucagon, or thyroid hormones. This determines its therapeutic potential. Growth hormone has anabolic and anti-catabolic properties. It promotes the growth of muscle and connective tissue, increases strength and energy levels.
When comparing this drug with recombinant human growth hormone, Sermorelin Acetate is less effective. During clinical trials, fewer patients responded positively to therapy than somatropin, with improvements being less pronounced. However, it would be a mistake to exclude Sermorelin acetate as a therapeutic option.
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For example, studies have found that Sermorelin acetate can significantly increase the growth rate in children with GH deficiency.
Moreover, these improvements persist after one year of therapy. Some patients develop antibodies to GHRH during long-term therapy, which may reduce the effect of the drug. However, the full biological nature of this antibody response remains unclear.
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Sermorelin is approved for the treatment of growth hormone deficiency in children only in the United States. Long-term studies involving adults are lacking. A study looks at the effects of Sermorelin acetate in a group of HIV + men with HIV lipodystrophy. It is characterized by an abnormal distribution of fat cells and decreased levels of growth hormone. During this study, 31 men aged 18 to 60 years received 1 mg Sermorelin acetate or placebo subcutaneously twice a day for 12 weeks.
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The initial result of the study was a significant increase in serum IGF-1 in the group receiving Sermorelin acetate (104 ng / ml vs. 6 ng/ml). This was accompanied by a favorable increase in body weight (+.9 kg vs. -.3 kg) and a decrease in visceral and subcutaneous adipose tissue. Sermorelin acetate was well tolerated and did not cause any change in other parameters, including blood pressure, cholesterol, triglycerides, insulin, or hemoglobin. None of the participants discontinued therapy due to side effects.
Sermorelin acetate may offer therapeutic advantages over recombinant growth hormone in some cases, in which it is less likely to lead to GH growth. This is because sermorelin therapy is based on the body’s natural hormone synthesis instead of external addition. Thus, natural IGF-1 reverse inhibition will help to establish natural levels of the growth hormone stimulating effect. These levels are more easily controlled with sermorelin acetate.
History of Sermorelin Acetate
Sermorelin Acetate was developed in 1980 and approved for distribution and sale by the FDA in 1997. It is marketed under the name Geref Diagnostic by the international biotechnology company Serono. As the name suggests, it is primarily a diagnostic tool. It is used to assess the potential deficiency in pituitary growth hormone production. In 2008 Serono ceased production of the product due to a shortage in the supply of active pharmaceutical ingredients.
How Sermorelin Acetate Works
Geref Diagnostic is available in ampoules containing lyophilized Sermorelin Acetate equivalent to 50 mcg Sermorelin. It is dissolved in a sterile solvent before use. The different versions of this medicine usually have 3 and 7.5 mg of lyophilized Sermorelin Acetate in a multi-dose vial. It is required to be converted into a suspension before use.