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SARMs Review

sarms reviewIn this SARMs review, we look at the legal situation surrounding SARMs and we ask the questions are SARMs legal?

Are SARMs Steroids?

Anabolic steroids have long been considered illegal unless they have been prescribed by a doctor for medical reasons. With the update of the Steroid Control Act, it is now legally no longer only in the gray area to sell prohormones. For some time now, selective androgen receptor modulators, or SARMS for short, have been the next big thing in research. This is due to them showing positive signs in medications that inhibit pathological muscle wasting and have potent anabolic effects.

SARMs – what is it anyway?

The abbreviation SARM means selective androgen receptor modulators. Basically, this means that they can dock to the androgen receptors, but are designed so that they only act selectively on certain representatives of these receptors. In the class of androgens we are dealing with steroid hormones such as testosterone, which are mainly responsible for the development of male sexual characteristics in the body such as reproductive organs, beard growth, increased muscle mass etc. An excess of androgens can also lead to side effects, such as an enlarged prostate or, in women, masculinization.

Natural androgens that the body produces itself can dock on all androgen receptors in the body. SARMs have been chemically designed by scientists so that they only have an effect in certain areas of the body. For example, attempts have been made to develop substances that only work in the muscle cells and bones and thereby increase muscle growth and bone density, whereas the prostate or hair follicle remains unaffected.

SARMs Bodybuilding

However, the background of the research was not to give bodybuilders more muscle mass but to provide sick people who suffer from muscle loss or recover from serious injuries with the safest possible alternative to androgen therapy. In medicine, testosterone and the like are traditionally administered to patients who do not naturally produce sufficient amounts of the hormone or who can benefit from the anabolic effects on muscle mass and bones in emergencies. However, it is difficult, for example, to apply testosterone therapy to a female burn victim, since she could then possibly suffer from irreversible masculinization symptoms in the long term.

Question: SARMs Side Effects

One can only speculate about the reasons why SARMs have so far hardly made it into human studies, despite extensive research on cells and animals. Some representatives initially showed promising results, but the experiments were only rarely transferred to humans. In order to obtain approval as a pharmaceutical, extensive research work on volunteers is required. Some proponents of selective androgen receptor modulators claim that the expected profit margin on corresponding products for the pharmaceutical companies is too small and therefore attempts are being made to slow down further development. We do not want to make any assumptions here.

The current legal situation in the USA

Since bodybuilding and the misuse of medication for the purpose of increasing performance are much more pronounced in the United States than in this country, SARMs are also a much bigger topic there. However, until April 24, 2018, there was no very precise regulation, which is why they could be legally sold and consumed until then. However, SARMs were never considered dietary supplements in the USA either, which is why some manufacturers were sued for placing such substances on the market as supplements. Declared as “research chemicals”, however, it was possible to distribute SARMs.

With the enactment of the SARMs Control Act, SARMS were included in the American Narcotics Act and therefore they now belong to the same category as cocaine, opiates or anabolic steroids. Selling, owning and consuming SARMs are therefore punishable in the United States. But what made the state take this decision?

The Story so Far…

Well, the push came from at least three different directions. The anti-doping facilities were obviously one of them. In January 2008, some SARMs such as Ostarine or Andarine were included in the WADA doping list. Since then, numerous athletes have tested positive for this class of substance. Obviously, the relevant national and international organizations want to reduce the availability of SARMs for athletes.

The second instance in favor of the ban is trade groups in the food supplement industry. The sale of SARMs, declared as “Dietary Supplements” or “Dietary Supplements”, as it is called was a thorn in the side of the majority of the industry, which provoked a change and new edition of the Dietary Supplement Health and Education Act (DSHEA), for which one had fought for years. However, selling SARMs as dietary supplements were illegal from the outset because they did not meet the criteria for this and the American Food and Drug Administration (FDA) has the power to take legal action against manufacturers and sellers.

SARMs for Sale

Then there are the “guard dogs” of health care. SARMs have been developed as medicines and, like all medicines and drugs; can have negative side effects. Unlike the FDA-approved drugs, many SARMs have not been studied extensively enough in clinical trials, as we mentioned earlier. As a result, unsupervised and non-prescribed use is considered risky, especially if the products do not come from the pharmacy, but from the underground laboratories of hobby chemists who buy their raw materials in China and sell them online.

Are SARMs Legal in the US?

It is, therefore, no surprise that the US legal body has passed the SARMs Control Act to prevent the spread and use of these substances. This does not mean that research in this area will not be resumed and continued, but it would still take years before approval as a drug, and even then SARMs would only be available as prescription drugs.

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A Guide to What Happens with a LGD 4033 Dosage

lgd 4033 dosageIn this guide, we look at the effect of SARM LGD-4033 dosage and delve into various studies that have taken place and logged the results. LGD 4033 is classed as a research chemical and like all of the members of the SARMs group are still being studied and not for human consumption. But, studies have shown them to have some positivity in treating various health problems. Want to know more then read on…

What is SARM LGD-4033?

LGD-4033 is also known as Ligandrol. It is a relatively new developed, orally consumable and non-steroid SARM. SARM or selective androgen receptor modulators bind easily and the ability to focus on the androgen receptors. This research chemical was originally developed to reduce muscle wastage, which increases dramatically in cancer patients through radiation and chemotherapy. It was also used against the spread of muscle loss in acute and chronically ill people. In addition to these two uses, it is also used worldwide to curb muscle age-related shrinkage.

SARM LGD4033 raises expectations by producing the same therapeutic advantages as testosterone, only with improved safety and increased tolerance due to the tissue-selective mechanism of action and greater patient acceptance compared to conventional testosterone simply because it acts as a prohormone rather than an anabolic steroid becomes.

A Study of LGD-4033

Those who have used LGD-4033 will have experienced increased muscle activity, improved anti-resorptive and build-up activity in the bones. It also has a more robust selectivity of the muscles and bones against prostate and sebaceous gland diseases.

A phase 1 study in healthy subjects was recently completed were randomly selected, double-blind and placebo-controlled led to the following result. It showed that doses of up to a maximum of 22 mg per day can be taken without any noteworthy side effects.

The age of LGD is much newer at 3-5 years than that of most comparable preparations available on the research market. This indicates unexplored territory and maybe potential danger. So far, LDG-4033 has undergone several different new studies. From these experiments, the results showed an increase in lean body mass and a decrease in body fat. Furthermore, it indicates an increase in well-being, an increase in strength and improved physical regeneration among users.

LGD-4033 Results

LGD4033 is possibly the SARM that has achieved the best results in muscle growth and general weight gain. The increase in muscle or mass is strongly dependent on the food supplied to the body. If the calorie intake is increased using LGD, the body gains a significant amount of mass within 8 weeks. Differences to testosterone are that it is not a steroid anabolic, but it is a prohormone that is able to massively and specifically support the building of fat-free muscles. The liver toxicity of the oral SARM is significantly lower than that of the previously commercially available oral testosterone preparations.

SARM LGD 4033 Side Effects

Taking lgd4033 has so far not resulted in any side effects or complications worth mentioning for any of the users. So far, water retention, weak acne or high blood pressure has only occurred in isolated cases. Due to the novelty of the SARM, nothing can be reported about the long-term consequences of regular use.

An Example of LGD-4033 Dosage

To maintain physical integrity where possible, the following must be observed when dosing:

  • In the bulk phase, 5-10mg can be taken daily for a total of 8 weeks
  • During the diet, the dose should be reduced to 3-5mg daily
  • To achieve the highest possible fat loss athletes make use of an lgd 4033 stack. Which means it is taken in combination with GW-501516 and S-4 in this phase

Further Studies of LGD-4033 before and after

The SARM LGD-4033 appeared on the scene later and completed phase I of the clinical trials, LGC-4033 proved to be well tolerated and showed no serious undesirable side effects in the test subjects. In terms of anabolic effectiveness, LGD-4033 demonstrated an impressive effect. For example, there was a significant increase in muscle mass and strength in a short period of time. LGD-4033 has been a success in every respect and there have been numerous positive user reviews since this active ingredient was launched on the peptide market.

The Study Results

In order to get a better overview of the effects of LGD-4033, let’s take a look at the highlights of the first round of clinical examinations. Eight male subjects participated in the study (six of whom received the active ingredient and two received placebo) and each subject received a different dose of LGD-4033. The doses administered were 0.1 mg, 1 mg, 5 mg, 10 mg, 15 mg and 22 mg per day. The test period was 2 weeks during which safety and tolerability were assessed.

In such a test, the effects of anabolic-androgenic steroids on cardiovascular health markers such as hematocrit value, blood pressure, hemoglobin and blood lipid levels are critical. After all, everyone wants to maintain good cardiovascular health. However, anabolic androgenic steroids often cause an increase in all of these markers. This is precisely why the development of SARMs is a priority for scientists.

LGD-4033 put to the test

Fortunately, LGD-4033 passed this test with flying colors and even with a high dose lgd 4033. The studies show that there are no changes in blood pressure, hemoglobin or blood lipid levels. However, it should be noted that at doses above 5 mg per day, HDL cholesterol levels (good cholesterol) fell below the standard reference value. However, these returned to normal after the drug was discontinued.

The effects of LGD-4033 on testosterone levels vary somewhat more. The testosterone values ​​remained at the standard reference range (270-1070 ng/dl) for doses below 5 mg per day. In contrast, at doses above 5 mg per day, the total testosterone levels decreased in the range of a clinical deficit. However, this does not mean that LGD-4033 has no effects on testosterone production at doses below 5 mg per day. It just means that this dosage range prevents subjects from falling into the clinical deficit range.

Other effects on testosterone levels

In reality, LGD-4033 causes a linear reduction in testosterone levels in all dosage ranges. The scientists claim that this reduction is not statistically relevant is inadvertently misleading. After all, this means that a person’s testosterone levels could have dropped from 800 ng/dl to 350 ng/dl. In this case, this massive drop in testosterone levels would have been ignored simply because the person would not have ended up in a clinical deficit (below 270ng / dl). However, these results are still significantly better than traditional anabolic androgenic steroids.

In addition, unlike most oral steroids, LGD-4033 is not methylated. Therefore, it does not have the liver toxicity that is typically present with methylated anabolic androgenic steroids. Confirmation of this was provided by an examination in which the scientists examined liver function both before the start of the study and after half of the study period. No significant change in liver function tests was found. Accordingly, this SARM can be used for longer periods without fear of liver disorders or liver damage.

LGD- 4033 Suppression and PCT

Most men experience prostate enlargement and increased PSA at some point in life. If that’s under control, it’s not a big deal. However, it can get serious if things get out of control. Steroids contribute to this problem by docking with and activating receptors in the prostate. This promotes prostate hypertrophy and exacerbates any diseases or problems such as prostate cancer. Those who are older or who already have prostate problems will be happy to hear that LGD-4033 has no effect on PSA levels. The reason for this is the high degree of selectivity for the muscles towards the prostate and other organs and body systems.

Where to Buy LGD-4033

Concluding this blog we are not promoting the use of any SARM, but reporting the facts that have been logged to date on its results. Primarily an LGD-4033 dosage has shown positivity and importance in having an anti-resorptive effect in the bones. This prevents the release of minerals back into the bloodstream and especially for osteoporosis. This could one day help many sufferers with this condition. If you are in the research chemical industry and searching for reputable companies with SARMs for sale check out Peptides USA. You will find a wide selection of peptides and products including lgd 4033 for sale at affordable prices!

 

 

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GW501516 Dosage Explained

GW501516 DosageIn this blog, we explore the research chemical known as a SARM and how a GW501516 Dosage works and why. GW-501516 is a prohormone and does not belong to the SARM family, but to the PPAR (Peroxisome Proliferator-activated Receptor) category.

The product GW501516 is also known as GW1516, Cardarine and Endurobol. These types of chemicals are popular because they are able to use significantly more glucose for the muscle, which benefits both endurance and muscle building. In addition, it is used due to its strong fat-burning properties, while at the same time having an anti-catabolic effect. Are you intrigued by this? Then everything you need to know on this product can be found here:

GW501516 Reviews

PPAR modulators, such as GW-501516, allow the body to provide more glucose for the muscle and build additional muscle tissue. It can help to reduce or even completely stop fatigue problems, obesity, and even diabetes pre-stages that have a negative effect on fat metabolism. It is used in medicine in the United States to effectively combat obesity and to cure obesity-related problems.

How GW-501516 (Cardarine) works

GW-501516 is a selective agonist with strong potency. It is able to optimize the regulation of proteins that are responsible for the energy supply in the body. This then drastically accelerates the entire metabolism, i.e. the fat metabolism. Due to its results, GW-501516 is used by bodybuilders and athletes to increase their endurance levels. Professional athletes are actually prohibited from using it because GW-501516 is on the doping list. The use of GW-501516 to reduce body fat is also very common and effective. Fat loss from this prohormone is definitely not linked to loss of muscle mass, as is the case with ephedrine, for example. On the contrary, GW-501516 is even expected to have anti-catabolic effects.

What is GW 50156?

SARM GW 50156 is a selective agonist of the so-called PPARδ receptors, which means that receptors of this type are increasingly activated. It is classed as a research chemical and not for human consumption. These receptors are responsible for the regulation of glucose and fat metabolism, which is, among other things, for the occurrence of fatigue during training sessions, which is often noticeable by muscle weakness. It doesn’t work on a hormonal basis. Therefore, it can be combined with other substances to optimize the effects of training more easily than most prohormones.

Cardarine before and after

Those who have taken this chemical have noted that a daily dose of 20 mg is sufficient. With this substance, the dosage for females and male users are the same. Since the substance is in liquid form and does not have to be injected, consumption is relatively easy. The desired dose is simply delivered to the mouth and from there it is fed into the stomach with a little water or juice.

  • Some athletes consume the entire 20 mg an hour before their workout.
  • Others split them up in the morning and evening to have more moderate effects throughout the day.
  • The recommended daily dose to increase endurance is 10 mg.
  • A dose of 20mg is recommended to increase fat burning.

A positive effect of this chemical is the reduction of diabetes pre-stages and the reduction in fat.

Example of GW-501516 dosage

We don’t promote the use of this or any other product similar to this for human consumption. This is for information purposes only.

  • To increase endurance – 10mg daily for the duration of the intake can be adjusted individually.
  • For effective fat reduction – 10-20mg a day for 8 weeks along with S4 and Ostarine will give maximum results.

What are the GW501516 side effects?

The side effects of GW501516 correspond to those of drugs, whereby the dosage and frequency of use should be considered. There has been more speculation about carcinogenic side effects. This remained speculation since none of the studies carried out to date have proven the accuracy of this argument. In 2008, all trials and research on Cardarine were discontinued after it was established that the drug developed tumors in all organs. This view seemed too one-sided to the supporters, who argued that the drug was administered in doses that were much too high.

Which side is actually right remains open or let’s say, and athletes like to ignore it! The developing company GlaxoSmithKline stopped the research because it classified the cancer risk as too high. Would they have done it if they found an ingredient that was actually revolutionary and that could have made a lot of money? Probably not, so you have to decide for yourself which side you believe.  Not much is known about other side effects of Cardarine in reality and hardly any user reports can be found.

Origin of GW 501516 Cardarine

Cardarine was first introduced in 2001. Up to 2009, the active ingredient had undergone numerous studies and research. Until it became known that Cardarine greatly increased the risk of cancer in animal experiments.

A look at the Cardarine Transformation

At the same time, however, it was found that the test animals had greatly increased endurance performance. But why do research at all? Actually, the active ingredient GW 501516 should be developed for the treatment of diabetes, fat metabolism disorders, and obesity. The professor responsible reported that in the mice that were taken as experimental animals, there was a strong regulation of the fat metabolism and that the mice could lose fat. However, this did not result in the usual catabolic effect. So no muscle-degrading effect was found. The mice showed that glucose was stored in the skeletal muscles and at the same time there was even an increase in muscle mass.

Effect of Cardarine GW 501516

The active ingredient has shown that the body uses fat instead of glucose (carbohydrates) to burn fat. At the same time, there is an increased uptake of glucose in the skeletal muscles. The effect is a low-fat, full appearance while increasing endurance and burning fat. What is interesting about Cardarine/ GW 501516 is that the active ingredient has a huge impact on fat burning without having to do any sporting activity.

Is it any wonder that the active ingredient GW 501516 is so popular with endurance athletes and bodybuilders?  In addition, fat loss should increase with the duration of ingestion. In the United States, the active ingredient is said to be quite popular among endurance athletes and GW 501516 the ultimate supplement. And if you want to go one better, combine Cardarine with Ostarine. But please at your own risk.

Summary: Cardarine GW 501516 Dosage

What dosage is recommended, or what goal do you want to achieve and are you interested in increased endurance or increased fat burning?  These questions should all be left in the hands of the professionals who test research chemicals like this for future treatments for conditions and diseases. If you are in the research industry then buy gw 50156 from the reputable Peptides USA store now!

 

 

 

 

 

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A Brief Guide of Ursodeoxycholic Acid Uses

Ursodeoxycholic Acid UsesThe main ursodeoxycholic acid uses include the treatment of small cholesterol-containing gallstones (cholelithiasis). Modern western societies average about 15 to 20% of people suffering from gallstone disease. Women are affected more often than men. In addition to the female gender, typical risk factors include overweight (obesity), old age (older than 40 years) and the presence of gallstones in first-degree relatives. In 80% of the cases, the gallstones are stones containing cholesterol. Symptoms only appear in about 25% of patients with gallstones. This typically results in an upper abdominal pain on the right side, which can also radiate into the shoulders or the back.

How Does Ursodeoxycholic Acid Work?

Gallstones are caused by an imbalance in the various substances in the bile. In addition to the bile acids, there are also dissolved substances (e.g. cholesterol) in the bile. A high proportion of cholesterol combined with a low concentration of bile acids leads to the stones containing cholesterol within the bile ducts.

Introduction – Ursodeoxycholic Acid Mechanism of Action

Ursodeoxycholic acid also occurs naturally in very low concentrations in the bile. It counteracts the formation of gallstones in various ways and also leads to the termination of small, cholesterol-containing stones. On the one hand, ursodeoxycholic acid inhibits the absorption of cholesterol from the intestine into the human body, while at the same time the release of cholesterol from the liver cells into the bile is reduced. Ursodeoxycholic acid stimulates the release of bile acids from the liver cells into the bile. The lower cholesterol and higher bile acid concentrations prevent the formation of cholesterol-containing gallstones and at the same time small, existing stones can be dissolved.

In addition, ursodeoxycholic acid uses include a cell-protecting effect by inhibiting chronic inflammatory reactions. Damaged liver cells can be protected by chronic inflammation and the progression of cirrhosis can be delayed.

 A Guide to Ursodeoxycholic Side effects

Serious side effects occur only very rarely during therapy with ursodeoxycholic acid. Average statistics are 1 in 10 of 100 patients experience side effects the main being diarrhea. This is due, among other things, to the inhibited absorption of cholesterol from the intestine into the body, as a result of which high amounts of cholesterol are excreted. The stool is often referred to as mushy by the patients concerned.

In very rare cases (less than 1 in 10,000 patients), calcification of the gallstones or hives may occur as part of the therapy. Patients with known cirrhosis of the liver (due to a backlog of bile) can also experience severe pain in the right upper abdomen. Worsening of cirrhosis of the liver is also possible in very rare cases and requires treatment to be discontinued.

Possible Ursodeoxycholic Interactions

The effectiveness of ursodeoxycholic acid can be impaired during treatment with bile acid-binding drugs. The bile acid-binding preparations include colestyramine. This has the property of binding and excreting the bile acids in the intestine. As a result, new bile acids have to be formed in the liver from cholesterol, which can lower the cholesterol level in humans. At the same time, however, ursodeoxycholic acid is no longer absorbed in the intestine and can therefore no longer cause the gallstones to dissolve within the bile ducts. For this reason, a delayed intake (at least 2 hours) is recommended.

Further interactions can arise through the metabolism of ursodeoxycholic acid via specific liver enzymes (e.g. CYP3A4), through which numerous other preparations are also metabolized. Studies have already reported an increased effect of ciclosporin and a weakened effect of ciprofloxacin or nitrendipine.

Summary

To recap UDCA or Ursodeoxycholic acid brand name is ursodiol. But this is only one there are over 50 brand names listed in Medindia’s drug directory. It is produced as a tablet form i.e. ursodeoxycholic acid 150mg and ursodeoxycholic acid 250mg. Other versions of the chemical can be found as an ingredient in capsules, creams, gel, liquid, and ointments.

For the raw ingredient for research purposes compare Ursodeoxycholic acid price now from the research chemical store Peptides USA!

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Toremifene for Sale at Affordable Prices

toremifene for saleAre you searching for the SERM Toremifene for sale from a reputable company? Then you have found the right place. Peptides USA is an online store with a wide selection of quality Peptides and research SERMs for sale.  Toremifene Citrate is a research chemical was originally developed as a cancer drug to help in the treatment of post-menopausal female breast cancer. Since then experts have found it to help benefit a number of other health conditions. Want to know more facts about his chemical then read on…

What is a SERM?

Toremifene is classed as a SERM or selective estrogen receptor modulator. It works by counteracting the effects of estrogen in the body.  The SERM Toremifene is classified as a triphenylethylene analog, the structure of which is very similar to Nolvadex (tamoxifen) and Clomid (clomiphene citrate). Toremifene (or Fareston) could be considered comparable to Nolvadex. Toremifene is also a non-steroidal compound.

Toremifene Mechanism of Action

Thie drug is classed as a breast cancer medicine in the treatment of post-menopausal female breast cancer. It is found to have a positive estrogen receptor (or an unknown estrogen receptor) and means that it is a drug used to block and treat female breast cancer.  This is enhanced by estrogen through the activity of estrogen at breast tissue receptors, which can promote cancer growth through the tissue growth-promoting activity in breast tissue. Toremifene binds to these receptor sites, as previously described. Then it blocks the ability of estrogen itself to further activate the receptor sites in breast tissue. Thereby blocking or stopping the progression of tumor growth that could be enhanced by estrogen.

What is Toremifene Citrate?

Licensed in the United States under the Fareston brand, toremifene citrate is approved for use in advanced FDA (metastatic) breast cancer. It is also being used to prevent prostate cancer under the brand name Acapodene.

Toremifene Bodybuilding Uses

This research chemical is also popular than anabolic steroids for bodybuilders and athletes for the same reasons as Nolvadex: it is used to combat and/or block the effects of excessive estrogen in the body due to the aromatization of various androgens used (such as testosterone or Dianabol). The SERM toremifene is mostly used to relieve and/or prevent the estrogen-related side effect of gynecomastia (development of breast tissue in men).

Toremifene citrate Buy Now

Toremifene citrate is a new compound that was approved by the FDA in 1997 as a prescription drug. It is the most popular medication in the US prescription drug market under the Fareston brand. GTx, Inc. This pharmaceutical company was the first and still is the current company to manufacture toremifene under the Fareston brand.

An Example of Toremifene Citrate Dosage

The recommended dose for the treatment of breast cancer is one 60 mg tablet administered once a day. Here are some other examples of how it is used:

  • The SERM Toremifene citrate is interchangeable with tamoxifen citrate (Nolvadex) during a cycle or in post-cycle therapy. The dose 20mg tamoxifen citrate equals 60 mg of toremifene citrate3 tablet. From dosage estimation, sixty milligrams should be sufficient for treatment for the prevention of gynecomastia (benign enlargement of male breast glandular tissue).
  • During steroid treatment athletes and bodybuilders use 30 mg to 60 mg a day. For use during toremifene pct users have anecdotal doses ranging between 60 and 120 mg per day.
  • Most users have reported that when using toremifene citrate for their post-cycle therapy, they will administer the drug for at least 3 weeks. A maximum length is not necessarily fixed due to the minor side effects associated with the connection. In this case, this connection can be operated as long as needed with little to no concern about possible side effects.

Toremifene side effects

As with all medication, there are often side effects that can occur. Common side effects include bone pain, constipation, depression, dizziness, dry eyes, hot flashes, hair loss, itching, nausea, rashes, swelling hands and feet, spinning sensation, swollen lymph nodes, vaginal bleeding, and vomiting.

Check out Peptides USA now and you will see it is the best place with toremifene for sale!

 

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6 Things You Need to Know About Tamoxifen

6 Things You Need to Know About TamoxifenIn today’s modern society there are many experts in the medical industry who are dedicated to finding cures for serious diseases and illnesses. In this blog, we look at the peptide tamoxifen citrate a research chemical that is an ingredient used in a tablet form to treat breast cancer. Here in this blog, we look at 6 important facts about the chemical Tamoxifen.

  1. Why is this medicine prescribed?

The drug Tamoxifen citrate is a chemical compound that was developed as a treatment of breast cancer. It was approved for use by the FDA or Food and Drug Administration and is one of the oldest treatments and the most prescribed.  This drug is used to treat men and women with hormone receptor-positive early-stage, breast cancer after surgery and to reduce the risk of cancer returning. It is also is diagnosed with patients with advanced stages of breast cancer (metastatic hormone-receptor-positive disease). Plus it is often recommended to women who haven’t been diagnosed with the disease but to lower the risk of developing breast cancer in high-risk cases.

  1. How does this drug work?

The drug is known in the industry as a SERM (selective estrogen receptor modulator). This works by either selectively blocking or activating estrogen action on certain cells. Tamoxifen blocks estrogen activity on breast cells but will activate estrogen action in the bone and liver cells. It has the ability to obstruct estrogen from functioning on non-cancerous cells. In cases of women with no history of breast, cancer tamoxifen can actually protect them from developing the disease. Please note that tamoxifen doesn’t respond to hormone receptor-negative breast cancer.

  1. When should you use this product?

This drug is not recommended for those who are; trying to get pregnant, could be pregnant, pregnant or breastfeeding. There is a chance tamoxifen can cause damage to the developing embryo. Birth control is suggested including condoms, diaphragm or I.U.D (non-hormonal birth control is best). However, if you can take the drug the tamoxifen side effects can include; bone pain, depression, fatigue, headache, hair thinning, hot flashes and nausea

  1. What you should know before using a tamoxifen citrate dosage

Tamoxifen citrate should be used with care in the following situations:

  • If a woman premenopausal period, because of menstruation can be interrupted.
  • In patients who use hormonal contraceptive methods to avoid pregnancy,
  • Women who suffer from vaginal bleeding or other gynecological symptoms
  • Are taking or have already taken tamoxifen citrate
  • There may be some changes in the wall of the uterus (endometrium)
  • Tamoxifen citrate may increase microvascular complications in surgery of breast reconstruction
  • The drug is not expected to affect the ability to drive vehicles and operate machinery
  • It should be used with care in patients taking anticoagulants.

 Beware of Tamoxifen Interactions

Finally, it is worth reporting if you are suffering from continual fatigue (tiredness) with the use of tamoxifen citrate. And care should be taken using at the same time as inhibitors as anastrozole, letrozole, and exemestane. Tell your doctor or dentist if you are using any other medication

  1. Best Place for Storage

Tamoxifen citrate should be maintained at room temperature between 15 and 30 degrees Celsius, and away from light and high temperatures. The expiry date is 24 months from the date of manufacture. The drug is available in tablet forms in 10 mg and 20mg strengths.

  1. How to take Tamoxifen Citrate Dosage

When patients are recommended the drug is often recommended in dosages of 20mg once a day or 2 doses of 10mg tablets. It is important not to break or chew the tablet. The medicine is commonly prescribed for 5 years after initial breast cancer treatment such as chemotherapy, radiation, and surgery.

Summary of Benefits

For over 20 years this drug has saved millions of men and women’s lives over the years. It is important to talk with your specialist about this product as each person is different. Here we conclude the benefits from Tamoxifen.

  • It can reduce the risk by 40% – 50% in postmenopausal women of breast cancer returning, and 50% in premenopausal women
  • Reduce new cancer forming in the other breast by 50%
  • Minimize large hormone receptor-positive breast cancer prior to surgery
  • Decrease the breast cancer risk in those who are high-risk cases
  • Slow down or stop the growth of advanced metastatic hormone receptor-positive breast cancer in pre- and postmenopausal women

Away from cancer Tamoxifen benefits include lowering cholesterol levels and reduce bone loss after menopause.

Find out the Tamoxifen 20 mg cost

This guide gives you an idea about how amazing medical research is. These facts explain how important study and testing are on certain research chemicals to help save lives around the globe. If you are in the research chemical industry and searching for tamoxifen citrate buy at the affordable price of $25.33 from Peptides USA.

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Sterile Water for Sale at Affordable Prices

Sterile Water for SaleAre you in the research industry and searching for sterile water with bacteriostatic water for sale? If so you have found the right place. Peptides USA provides the best quality products for research purposes only. Browse the shop and see what is available. For example, you can buy Sterile Water X 30ml (25% BA) at an affordable cost of $14.33. A bargain isn’t it? Are you are an expert in this field? Then you will know that sterile water is important to dilute chemicals for injection purposes. For professionals in the medical world, it is essential for this product to be available. If you are new to this business read on for more facts about sterile water.

What is Sterile Water?

Sterile water is a highly purified solution, as the word implies. There is nothing added to this solution, no additives or preservatives. And as we mentioned earlier it is needed to weaken chemicals such as peptides prior to being injected. When a vial of sterile water it opened it should be used at once. If there is any left it needs to be thrown away. This is why vials of sterile water are only available in low amounts such as milliliters.

Possible Side Effects

The sterile water is comparatively safe. The main side effects noted are inflammation in the area of the injection when peptides are diluted and injected into the muscle. Some reports suggest other minor side effects can occur such as:

  • Allergic reactions (tightness in the chest, swelling of the mouth, face, and lips)
  • Electrolyte imbalance
  • Fever
  • Fluid overload
  • Low blood sodium also is known as Hyponatremia
  •  Redness at the site of injection

Bacteriostatic water vs. Sterile Water

For people new to this there is a big difference between sterile water and Bacteriostatic water.  But, the one important factor is that they are both sterile water, used to weaken medicine and chemicals for injection purposes.

What is Bacteriostatic Water?

Bacteriostatic water is highly purified and sterilized for diluting medicines that need to be injected. This water contains 0.9% benzyl alcohol. Benzyl alcohol is added to avoid any bacteria growing in the water. Then when the bacteriostatic water added to the medicine it is safe to inject into either intramuscular, intravenously or subcutaneously. Benzyl alcohol is an essential ingredient when diluting medicine to avoid major health problems. If any water is tainted it could cause serious health problems. A good example to consider is when a vial of bacteriostatic water is opened the benzyl alcohol stops bacteria forming for up to 28 days!

Side effects caused Bacteriostatic Water?

Like sterile water, the Baceriostatic is relatively safe. Side effects that may occur can include; abscesses, fever, infected area where injected, and venous thrombosis. One important note is that bacteriostatic water should always be used with medication because the benzyl alcohol in the water will break down red blood cells.

Which is the Best?

For many professionals sterile water is the first choice to combine medicine with because it has no other ingredient or microbes in it. It comes in a single-use vial so it can only be used once to avoid contamination. However, it is not suitable to inject into the body alone as it can cause blood cells to divide and upset the body’s balance.

Generally, experts will use the other option bacteriostatic for diluting most medicines and chemicals. The main reason is it provides better solubility. This product is sterile water but with the addition of benzyl alcohol. This stops bacteria or any other agent rowing in the vial.

Summary

You can buy Sterile Water X 30ml (25% BA) which contains 25% of bacteriostatic water for all of your medical research needs from Peptides USA.

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Raloxifene Blogs Positive News

Raloxifen blogsOur Raloxifene blogs about the positive outcome of this research chemical. Plus how it can help treat osteoporosis and more. Read on for more…

The chemical Raloxifene is a research chemical and can be successfully used as a selective estrogen receptor modulator in postmenopausal women against vertebral fractures. But that’s not all. New studies are now also examining its use in the prevention of cardiovascular diseases and breast cancer.

Evista Reviews

For many countries therapy for osteoporosis is still in its infancy. Therapy is denied even to high-risk patients. Patients who have already had a vertebral fracture or a fracture of the femur often do not even receive calcium or vitamin D, let alone the urgently needed movement therapy or effective pharmacotherapy. There are hardly any scientific reasons for this because there are some active ingredients available, and the effectiveness of which is beyond question. There are excellent study results for the selective estrogen receptor modulator (SERM) raloxifene (Evista) and the bisphosphonates. The data situation for estrogens is classified as moderate. All of these substances belong to the “resorption inhibitors”, and stop the bone breakdown, which is promoted by excessive osteoclast activity.

Choosing the Right Medicine – SERMs Osteoporosis

The choice of the right medication for the respective patient is decisive for the success of the therapy. Women are usually victims of osteoporosis (widow’s hump). This is because estrogens have a low, but significantly increased risk of malignancy. For example, they are not suitable for women with an increased risk of breast cancer. There are many doctors that prescribe one 60 mg Evista tablet daily (taken anytime) of the brand name Evista to treat osteoporosis.

Raloxifene Dosage for Vertebral Body Fractures!

The SERM Raloxifene has an estrogen agonistic effect on the bones and cardiovascular system, an antagonistic effect on the breast and uterus. The reason is similar to the sympathetic nervous system, where alpha and beta receptors exist, and also different estrogen receptors. While the beta receptors predominate in bones and blood vessels, the alpha receptors in the tissues of the breast, uterus, and liver. Raloxifene selectively attacks the beta receptors.

Study and Research: Raloxifene Review

The MORE study, published in late 1999, showed what can be achieved with this principle of action. 7705 women were involved, two-thirds of whom “only” had a pathological bone density (T-Score -2.5SD) and one third already had a vertebral body fracture. In addition to calcium and vitamin D, they received randomly 60 mg or 120 mg raloxifene or placebo for three years. Raloxifene reduced the rate of vertebral fractures by 30 to 50 percent during this period. It was 6.6 percent below 60 mg raloxifene, 5.4 percent below 120 mg raloxifene and 10.1 percent under placebo. Non-vertebral fractures, such as hip fractures, femoral neck fractures or forearm fractures, occurred approximately equally frequently in all study groups.

Positive Study Results with Raloxifene Osteoporosis

Our Raloxifene blogs the amazing fact that this is particularly suitable for younger postmenopausal women with an increased risk of fracture of the spine. Its advantage over hormone replacement therapy: it neither stimulates the mammary gland tissue nor does it lead to the proliferation of the endometrium. However, raloxifene is contraindicated in women who suffer from menopausal symptoms, for example, because hot flashes can be increased.

RUTH: Raloxifene reduces the risk of heart attack

However, osteoporosis will probably not remain the only indication for SERMs. With the discovery of the various estrogen receptors, the possible uses have expanded considerably. At least in the animal model, raloxifene dilates the vessels – at least in part through an increased release of vascular-dilating NO. The lipid profile also appears to improve with raloxifene: For example the total cholesterol, LDL cholesterol, and lipoprotein decreased by six to twelve percent, while HDL cholesterol increases by 15 to 17 percent.

Homocysteine, also an independent risk factor for cardiovascular diseases, is also kept within the normal range. The RUTH (Raloxifene Use for the HEART) study in 10,000 postmenopausal women with an increased risk of CHD is currently investigating whether these effects are also clinically evident.

STAR: Raloxifene to Prevent Breast Cancer?

Raloxifene, because of its estrogen-antagonistic properties, similar to tamoxifen, could also be suitable for the therapy and prevention of breast cancer. In the MORE study, raloxifene reduced the risk of breast cancer, in particular, the risk of estrogen receptor-positive tumors, by a remarkable 76 percent within 40 months. Long-term effects are now recorded in the continuing CORE (Continuing Outcomes Relevant to Evista) study.

A study recently launched by the National Cancer Institute, the STAR (Study of Tamoxifen and Raloxifene) study, compares the preventive effects of tamoxifen and raloxifene in 22,000 postmenopausal women with an increased risk of breast cancer. Particular attention is paid to the effect on the endometrial tissue. While tamoxifen can promote proliferation and thus bleeding and carcinogenesis, raloxifene is clearly antagonistic in this organ.

Raloxifene Side Effects

As with all medicine there, the pros and cons involved with new drugs and not everyone can take them. They are not recommended during pregnancy and breastfeed. Also, Raloxifene contraindication can occur if combined with other medications such as birth control pills, blood thinners, cholestyramine, diazepam, diazoxide and HRT (hormone replacement therapy). Possible side effects that can occur with an Evista/Raloxifene dosage are:

  • Dizziness, Excessive sweating, Headaches, Hot flashes, Joint pain, Leg pain, Nausea, Runny Nose, Spinning sense, stomach pain, and Sickness.

Rare side effects include; blood clots in the eyes, lungs and legs and strokes. It is important to seek medical advice if any of the following side effects occur:

  • Breathing problems, chest pain, confusion, leg swelling, severe headaches, vision changes and weakness sensations in the body.

Raloxifene Blogs Summary

As we mentioned early on in this blog the chemical Raloxifene has shown huge positivity as an ingredient for the future in treating not only osteoporosis but other serious diseases.

 

 

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An In-Depth Guide to Pramipexole Uses

pramipexole usesThe active ingredient pramipexole uses are mainly to treat Parkinson’s disease. As a so-called “dopamine agonist”, it mimics the effect of the naturally occurring messenger substance dopamine. This Parkinson’s drug is recommended as the standard of care for patients under 70 years of age. Here you can read everything important about the effects and use of pramipexole, side effects, and interactions.

How Does Pramipexole Work?

Parkinson’s disease is associated with a disruption of movement and a lack of movement. It is essentially based on the death of certain regions of the brain that control these movements. The so-called “black substance” (“substantia nigra”) in the midbrain largely consists of nerve cells (neurons) that communicate with other nerve cells via the messenger substance dopamine. On the one hand, they form a control loop with themselves to control the release of the messenger substance. But, they are also connected to other parts of the brain (especially the striatum) in order to coordinate movements.

Pramipexole – A Treatment for Parkinson’s Disease

In the early stages of Parkinson’s disease, pramipexole mainly acts on the control circuit for self-regulation. By pretending that there is sufficient dopamine, it prevents the remaining nerve cells from overexerting themselves and producing dopamine until they are exhausted. In the late stages of Parkinson’s disease, a large part of the dopamine-releasing cells in the substantia nigra have already died. In this case, pramipexole acts directly on the striatum nerve cells as a replacement for the dopamine that was once released there.

Studies show that pramipexole, like levodopa, which is also used in Parkinson’s disease, can also be used to treat restless legs syndrome (RLS, “restless legs” syndrome). Recent observations also indicate a positive influence on depression and bipolar disorders.

What Happens with a Pramipexole Dosage

After ingestion, pramipexole is absorbed into the bloodstream via the intestine.  Here it reaches its highest levels between one and three hours. From there it reaches the brain via the blood-brain barrier. Pramipexole is not significantly broken down in the body. After eight to twelve hours, about half of the active ingredient is excreted unchanged in the urine via the kidneys.

When is Pramipexole used?

The active ingredient pramipexole is approved for the treatment of Parkinson’s disease, both alone and in combination with levodopa. It can sometimes counteract or mitigate the fluctuations in effects typical of levodopa in the later course of treatment (“on-off phenomenon”). Pramipexole uses also are approved for the treatment of restless legs syndrome. The application should be continuous and long-term.

A Guide to How Pramipexol is used

The Parkinson drug Pramipexole is taken in the form of tablets. The start of therapy is insidious, which means: Starting with a low dosage, which is then slowly increased to the optimal dosage. It is taken in the morning, at noon and in the evening regardless of meals. The maximum total daily dose is 3.3 milligrams of pramipexole (calculated as salt form 4.5 milligrams). When combined with levodopa, lower doses are usually required. Delayed-release tablets (“prolonged-release tablets”) only need to be taken once a day. They slowly release the active ingredient throughout the day. To treat restless legs syndrome, a low dose is taken two to three hours before bed.

 What are Pramipexole Side Effects?

Pramipexole therapy, like many other Parkinson’s therapies, also has side effects. Over ten percent of the patients experience nausea, dizziness, movement disorders and sleepiness.

Other possible side effects of Pramipexole include impulse control disorders, compulsive behavior, confusion, hallucinations, insomnia, headache, visual disturbances, low blood pressure, constipation, vomiting, and fatigue, water retention in the tissues (edema), weight loss and reduced appetite.

Pramipexole Interactions

The active ingredient pramipexole doesn’t interact with other active ingredients because it is not or hardly broken down by the body. Active substances that block excretion via the kidney can lead to increased pramipexole blood levels. This may make it necessary to reduce the dosage. These substances include:

  • Heartburn cimetidine
  • Parkinson and flu agent amantadine,
  •  The cardiac rhythm active agent’s mexiletine, quinidine, and procainamide,
  •  HIV drug zidovudine
  • The cancer drug cisplatin

Active substances against psychosis and schizophrenia should not be combined with pramipexole. The reason is they have an exactly opposite effect and worsen Parkinson’s disease.

Sleep attacks may occur during pramipexole therapy. Therefore, patients should not drive vehicles or operate heavy machinery during treatment.

Children and adolescents under the age of 18, pregnant women and nursing mothers should not take pramipexole. The safety and effectiveness of the drug in these groups of people have not been adequately studied. Elderly and patients with mild to moderate renal impairment may take pramipexole. Dosage may need to be reduced in patients with severe renal impairment.

How to get medication with Pramipexol

Medications with the active ingredient pramipexole dihydrochloride are prescription-only in every dosage. The pramipexole brand name is Mirapex. The fact that pramipexole uses finally result in a treatment for serious conditions like Parkinson’s disease is what research into drugs is all about. Peptides USA only stock the raw chemical for study and research and not for human consumption.

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A Brief Guide to a Liothyronine Dosage

liothyronine dosageA Liothyronine dosage will be used as a supplement that replicas the natural thyroid hormone. The man-made research chemical liothyronine is a synthetic form of the human T3 hormone.

This type of drug is needed when the thyroid gland is injured from medication or radiation, or if it is removed by surgery. It also helps treat those with the underactive thyroid gland. It is crucial to have healthy levels of thyroid hormone to stay fit and healthy. For children having enough thyroid hormone is important for growth and the ability to learn properly.  The research chemical is an ingredient that can be found in the brand name CYTOMEL tablets (liothyronine sodium).

Experts Liothyronine Experiences

Often thyroid hormones can be distinguished into two categories, natural preparations from animal thyroid, and or man-made substances. The tablet form Cytomel contains the man-made thyroid hormone. This is used because some patients can be allergic to the extracts from the animal preparations.

Most endocrinologists prescribe the T3 drug Liothyronine dosage or the extract Armor Thyroid to patients who respond positively to combination therapy or thyroid extract. These experts who deal with thyroid problems know that this treatment has a good effect on their cognitive and psychological functions. They are then permitted to continue with the treatment in controlled doses. Armor Thyroid is a natural hormone mixture of T3 and T4 extracted from the thyroid to the pig. Thyroid extract can be given by GPs to supplement Levaxin or Euthyrox.

Liothyronine Reviews from a Study

In the past, the first drug for low metabolism was animal extract. It saved the lives of many, and it took several years before synthetic medicine came onto the market. Unfortunately, there are not many patient studies on the extract, and little research has been done on this treatment. The challenge is twofold – Thyroid extract is not a registered treatment in some countries and an exemption must be sought for each patient. The treatment is therefore expensive.

Testing on the substance in Norway by experts has shown this treatment immediately turns off the pituitary gland and creates imbalances in the blood tests. The pituitary test TSH has so far been the best treatment constraint. But it is hard for a physician to make good dosage suggestions. If a patient was prescribed this treatment with thyroid extract, it would be very important to have regular monitoring from a doctor. Some researchers have given T3 treatment next to the T4 medicine, without reducing the T4 dose as much. When treated with T3 in the morning, the effect will come in the daytime. The feedback from many patients is that they get more energy after starting combination therapy.

Other treatments with Liothyronine Weight loss

Doctors prescribe a Liothyronine dosage in tablet form for:

  • Low thyroid hormone or hypothyroidism
  • Prevent goiter – an enlarged thyroid gland
  • Thyroid disorders
  • Obesity
  • Depression

A positive point is that most people can take liothyronine as the thyroid hormone exists naturally in the body. But, it is essential to inform your doctor if you are suffering from any existing health condition, plus any other medication you may be taking.

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